Stem Cell Biology and Tissue Engineering in Dental Sciences

Stem Cell Biology and Tissue Engineering in Dental Sciences

Stem Cell Biology and Tissue Engineering in Dental Sciences bridges the gap left by many tissue engineering and stem cell biology titles to highlight the significance of translational research in this field in the medical sciences. It compiles basic developmental biology with keen focus on cell and matrix biology, stem cells with relevance to tissue engineering biomaterials including nanotechnology and current applications in various disciplines of dental sciences; viz., periodontology, endodontics, oral & craniofacial surgery, dental implantology, orthodontics & dentofacial orthopedics, organ engineering and transplant medicine. In addition, it covers research ethics, laws and industrial pitfalls that are of particular importance for the future production of tissue constructs. Tissue Engineering is an interdisciplinary field of biomedical research, which combines life, engineering and materials sciences, to progress the maintenance, repair and replacement of diseased and damaged tissues. This ever-emerging area of research applies an understanding of normal tissue physiology to develop novel biomaterial, acellular and cell-based technologies for clinical and non-clinical applications. As evident in numerous medical disciplines, tissue engineering strategies are now being increasingly developed and evaluated as potential routine therapies for oral and craniofacial tissue repair and regeneration. Diligently covers all the aspects related to stem cell biology and tissue engineering in dental sciences: basic science, research, clinical application and commercialization - Provides detailed descriptions of new, modern technologies, fabrication techniques employed in the fields of stem cells, biomaterials and tissue engineering research including details of latest advances in nanotechnology - Includes a description of stem cell biology with details focused on oral and craniofacial stem cells and their potential research application throughout medicine - Print book is available and black and white, and the ebook is in full color This work bridges the gap between dental science and stem cell and tissue engineering Dr. Ajay Vishwakarma is a researcher specializing in stem cell bioengineering, biomaterials, tissue engineering, cancer immunology, and immuno-engineering. He is affiliated with the Division of Engineering in Medicine, Department of Medicine, at Brigham and Women’s Hospital, Harvard Medical School, and the Harvard-MIT Division of Health Sciences and Technology. Dr. Vishwakarma earned his DDS from Maharashtra University of Health Sciences and an MSc in Tissue Engineering from Cardiff University, UK. He advanced his research on mesenchymal stem cells during his fellowship in the Khademhosseini Laboratory at Harvard-MIT. Currently pursuing a PhD in Cancer Biology at the University of Iowa, he investigates regulatory T cells in cancer progression under Prof. Weizhou Zhang. A recipient of multiple prestigious fellowships, Dr. Vishwakarma is also co-founder of OCTE Technologies , a biotech start-up developing next-generation cell and tissue engineering therapies. Professor Paul Sharpe is the Dickinson Professor of Craniofacial Biology at Kings College London. He graduated with a degree in biology from York University (1977) and a PhD in biochemistry from Sheffield University (1981). Following postdocs in Sheffield, Wisconsin and Cambridge he became lecturer in molecular embryology at the University of Manchester in 1987 where he established a research group working on the molecular control of tooth development. Following promotion to Reader in 1991 he was recruited to his present Chair at the Dental Institute of Guy’s Hospital (later to merge with Kings College), where he established a new basic research department, the Department of Craniofacial Development and Stem Cell Biology. The department, of which he remains head, now consists of 13 academic research groups with over 80 research staff. From 2002-2008 he was Director of Research for the Dental Institute. His main research interests are the molecular control of tooth development, dental stem cell biology and tooth bioengineering. He has published over 270 research papers including articles in Nature, Science, PNAS and Cell press. He has supervised over 40 PhD students and receives funding from the MRC. He is a member of the MRC Centre for Transplantation and Biomedical Research Centre. In 2004 he was awarded the Craniofacial Biology Research Award by the International Association for Dental Research in recognition of his contribution to the understanding of how teeth develop and in 2006 his paper “Stem cell-based tissue engineering of teeth” received the William J Gies award for best publication is Biomaterials and Bioengineering from the same organisation. He is on the editorial boards of several journals including J. Dent. Res. and J. Clin. Perio. Songtao Shi, D.D.S., Ph.D., is Professor at the University of Southern California Ostrow School